Biochemical pregnancy is a phenomenon that women should be aware of during fertility preparation. It refers to an early pregnancy that ends spontaneously before clinical confirmation of intrauterine implantation, i.e., a positive serum or urine β-hCG not followed by ultrasonographic evidence of gestation. Many women experience only a slight delay in menstruation and may remain unaware that a biochemical pregnancy has occurred. Scientific fertility preparation can help reduce the incidence of biochemical pregnancy and support overall reproductive health.
The principal causes of biochemical pregnancy are embryonic chromosomal abnormalities, maternal factors, and paternal factors. Embryonic aneuploidy is the most frequent aetiology and is often related to oocyte or sperm quality. Maternal contributors include age-related decline in oocyte quality, endocrine imbalances, and suboptimal uterine receptivity. The quality of the father’s sperm is equally important. If the sperm quality is poor, the fertilized egg may not develop normally, which may lead to biochemical pregnancy.
Following a biochemical pregnancy, implementation of evidence-based fertility preparation is particularly important. A comprehensive clinical assessment is recommended, including appropriate diagnostic investigations to identify underlying factors. Lifestyle optimisation—regular sleep patterns, balanced nutrition, and moderate physical activity—forms the foundation of management. Ovulation monitoring facilitates identification of the optimal conception window.
Targeted nutritional supplementation may serve as an adjunctive component of fertility preparation. For example, Juvenex Reco18 contains the patented Reco18 compound, a small-molecule extract derived from leguminous plants. Published research indicates that it may support oocyte quality and the follicular microenvironment, thereby providing a nutritional foundation for improved reproductive outcomes. The better the quality of the egg and the lower the aneuploidy rate, the stronger the embryo’s developmental potential, and the more likely it is to successfully pass through the “biochemical stage” and continue to develop into a clinical pregnancy. Such supplementation should be integrated within an individualised, physician-guided fertility preparation framework.
In addition to lifestyle modification and necessary medical evaluation, maintenance of psychological well-being is critical. Excessive anxiety can have adverse effects on endocrine balance and increase the risk of biochemical pregnancy. Recurrent biochemical pregnancy warrants referral to a reproductive endocrinologist for advanced diagnostic assessment.
In summary, biochemical pregnancy represents a common early reproductive challenge. Through scientific fertility preparation—encompassing comprehensive evaluation, lifestyle optimisation, timely monitoring, and evidence-based nutritional support (e.g., JuvenexReco18)—the likelihood of successful clinical pregnancy can be significantly enhanced. Scientific fertility preparation is a systematic, individualised, and proactive approach to managing biochemical pregnancy and promoting healthy reproduction.
