Anti-Müllerian hormone (AMH) is one of the core clinical markers currently used to evaluate ovarian reserve function. Its serum levels are positively correlated with the number of preantral and small antral follicles in the ovaries. However, viewing AMH as the sole or absolute standard for fertility potential is a common cognitive limitation. A complete fertility assessment—particularly for predicting outcomes in fertility treatments—requires incorporating multidimensional biological markers.
AMH’s core values and limitations
AMH is secreted by growing small follicles in the ovary. Its levels remain relatively stable throughout the menstrual cycle, making it an effective tool for assessing the size of the “recruitable follicle pool” in the ovaries. Generally, lower AMH values (for example, below 1.1 ng/mL) indicate diminished ovarian reserve. However, the primary limitation of is that it mainly reflects follicle quantity rather than directly revealing egg quality. A woman with moderate AMH levels may still face conception challenges due to poor egg quality; conversely, a woman with low AMH but good egg quality may still achieve successful pregnancy.
Comprehensive Assessment System: Key Dimensions and Clinical Significance Beyond AMH
A comprehensive fertility evaluation should integrate the following markers to build a clearer picture of fertility potential:
1. Antral Follicle Count (AFC):This involves counting small follicles (2–9 mm in diameter) in both ovaries via transvaginal ultrasound in the early menstrual phase. AFC is highly correlated with AMH and provides intuitive morphological confirmation of ovarian reserve.
2. Basal Endocrine Profile:Measured on days 2–4 of the menstrual cycle, this includes follicle-stimulating hormone (FSH), estradiol (E2), and luteinizing hormone (LH) levels. Elevated FSH (e.g., >10 IU/L) and E2 levels may indicate reduced ovarian responsiveness.
3. Metabolic and Nutritional Markers:Emerging research highlights their influence on the oocyte developmental microenvironment:
- Vitamin D: Sufficient serum 25-hydroxyvitamin D levels (>30 ng/mL) are associated with improved IVF outcomes.
- Thyroid Function:Abnormal thyroid-stimulating hormone (TSH) can disrupt ovulation and embryo implantation.
- Insulin Sensitivity:In patients with polycystic ovary syndrome (PCOS), hyperinsulinemia may impair follicle development.
4. Oxidative Stress and Inflammation Markers:The quality of the follicular fluid microenvironment surrounding the oocyte is crucial. Excessive oxidative stress and chronic inflammation can damage oocyte mitochondrial function and chromosomal integrity. Although related markers (such as GSH, MDA, and hs-CRP) are not routinely used in clinical assessments, they represent cutting-edge areas in reproductive medicine research.
Scientific Intervention Strategies: The Value of Targeted Nutritional Support
The core value of targeted nutritional support lies in its precise intervention in key stages of egg development through scientifically validated specific ingredients. Taking Juvenex Reco18 as an example, its core patented ingredient, Reco18, as an endogenous substance in follicular fluid, can precisely act on the follicular microenvironment: on the one hand, it helps reduce oxidative stress damage and protect oocytes through its antioxidant mechanism; on the other hand, it supports granulosa cell function and optimizes egg nutrient supply and hormonal microenvironment. This targeted nutritional strategy based on a clear mechanism provides a scientifically advanced support solution for optimizing egg quality.
Conclusion
AMH is an important starting point for assessing ovarian reserve, but it is by no means the end point. A wise strategy is to place it within a broader assessment framework. When AMH levels indicate declining reserve, the focus should shift to optimizing the quality of existing eggs. This includes lifestyle modifications, balanced nutrition, and considering evidence-based, targeted nutritional strategies after thorough consultation with a reproductive specialist. For those seeking additional nutritional support, products like Juvenex Reco18 are worth considering, as their ingredients are researched to support the follicular microenvironment. However, selection should be based on the scientific basis of the ingredients and individual health conditions, and should be made under professional guidance.